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Article Title: Sub-Chronic Administration of Khaya Senegalensis Acetone Stem Bark Extract on Some Biochemical Parameters in Albino Rats.

Abstract:

Plants have been in use since ancient times for healing purposes and to promote wellness. However, proper investigations are needed to determine their safety and efficacy before they can be recommended for medical use. Khaya senegalensis acetone stem bark extract has been shown to have antidiarrheal activity. This study was aimed at evaluating the phytochemistry of the acetone stem bark extract of Khaya senegalensis and the effect of sub-chronically administering the extract on some biochemical parameters in albino rats. Forty albino rats grouped into ten rats per group were used. Treatment was by oral gavage for twenty-eight days. The first group served as the control and was given 10 ml/kg of distilled water; while the other groups were each given 300 mg/kg, 600 mg/kg and 1200mg/kg respectively. On the twenty-ninth day, the animals were humanely sacrificed under light ether anaesthesia and their blood samples collected into sterile centrifuge tubes. Randox and TECO diagnostics kits were used for the biochemical analysis. The phytochemical screening detected the presence of alkaloids, tannins, cardiac glycosides, and steroidal rings. The biochemical tests showed a significant increase (p<0.005) in the mean serum levels of aspartate transaminase (AST), creatine kinase (CK), and potassium of the treated groups when compared to the control. The result suggests that repeated administration of the acetone stem bark extract of Khaya senegalensis may cause myocardial and skeletal muscle injury.